The X-Men have taken down super villains, aliens and their own future selves - but never all at the same time! Longtime X-foe Lady Deathstrike returns - while Karima struggles to remember herself, Rachel comes to terms with her relationship with Sublime, and a new member joins the team! Lady Deathstrike has assembled a new Sisterhood, her own illuminati to take down the X-Men and enslave the world. And Psylocke is first in the Sisterhood's crosshairs! Recruiting the likes of Typhoid Mary and Enchantress, Deathstrike's cabal goes on a global hunt for the most powerful ally of all - an enemy who holds the X-Men responsible for her near-destruction! But when this foe awakens, will either team be able to handle her?